Female Hormone Estrogen Blocks Ebola Virus Infection

estrogen-blocks-ebola-virus

Researchers have discovered that drugs containing female estrogen block infection with the Ebola virus, a deadly disease for which there is no cure.  Scientists stumbled upon estrogen as a potential weapon against Ebola while looking to find new uses for old drugs.

Ebola hemorrhagic virus is named after a river in the Democratic Republic of Congo in Africa, the continent where the disease is endemic.  The infection, discovered in 1976, is extremely deadly, with a mortality rate of up to 90 percent.  And amid concerns that the highly lethal virus could be weaponized by bioterrorists, scientists have been looking for ways to prevent infection with Ebola.

Lisa Johansen, director of research programs at Zalicus, a biotechnology company located in Cambridge, Massachusetts, says she and researchers at the U.S. Army Medical Research Institute of Infectious Diseases in Maryland and at the University of Virginia in Charlottesville screened 2,000 existing drugs, looking for chemical compounds that were effective against Ebola.

Investigators discovered that a number of human-made drugs, including selective estrogen receptor modulators, or SERMS, blocked Ebola’s entry into cells in lab cultures and in mice.

But it wasn’t the estrogen drugs’ hormonal activity that thwarted the Ebola virus, preventing infection.

Rather, Johansen says it was the compound’s chemical structure, and the structure of a number of other drugs, that hindered the microorganism, something that surprised researchers.

“I think that’s one of the things that’s exciting…When we looked at our inhibitors, we found that a lot of them are entry inhibitors.  And a lot of them have the structure even though the mechanism is for something completely unrelated,” Johansen said.

SERMS are so-called designer drugs designed to act like estrogen without negative side effects.  For example, Tamoxifen is an older SERM used to treat breast cancer and the newer Reloxifen is approved for the prevention and treatment of the bone-weakening condition osteoporosis.  But they have potentially serious side effects such as an increased risk of other types of cancer.

Johansen envisions using SERMS and other repurposed compounds in a number of situations to prevent infection and death.

“I think they could be used both by a civilian population where outbreaks are as well as potentially by the military if they were in an area where there was an outbreak and they went in to intercede, or if somebody used them for bio-warfare,” Johansen said.

An article on using estrogen drugs and other compounds to prevent Ebola virus infection is published in the journal Science Translational Medicine.


Fikradaha Akhristayaasha (0)


Comments are closed.

Wararka

Xassan Daahir Aweys oo siweyn uga horyimid dilalka ay geystaan Al-shabaab
- Apr 25, 2018
Sheekh Xassan Daahir Aweys oo horay uga tirsanaa hogaamiyayaasha sar sare ee kooxda Al-shabaab ...
Wasiirka Wasaaradda Wax-barashada Hiddaha & tacliinta Sarre oo soo gaaray gobolka Minnesota ee dalka Mareykanka
- Apr 23, 2018
Wafdi uu hoggaaminayey  Wasiirka Wasaaradda Waxbarshada Hiddaha iyo Tacliinta Sare ee dowladda Federaalka  Somaliya ...
Somalia calls for UN action against UAE base in Berbera
- Mar 27, 2018
Somalia has urged the United Nations Security Council to take action against the construction ...
C/wali Muudey oo iclaamiyay xilliga Baarlamaanka la horkeenayo Mooshinka Guddoomiye Jawaari
- Mar 25, 2018
Gudoomiye ku xigeenka 1-aad ee golaha shacabka Cabdiweli Ibraahim Muudeey ayaa qoraal uu soo ...
Sidee buu noqon doonaa Mustaqbalka Baarlamaan iyo Guddoonkiisa qeybsan yahay ?
- Mar 24, 2018
Tan iyo markii uu soo if baxay Mooshinka laga keenay Guddoomiye Jawaari ayaa waxaa ...
14 people killed in bomb blast in Somali capital
- Mar 22, 2018
  At least 14 people have been killed and several others were injured when a ...
DAGAAL u Dhaxeeya NISA iyo Ciidamada uu tababaray Imaaraadka oo ka socda degmada Hodan
- Mar 21, 2018
Is rasaaseyn culus ayaa waxaa ay muddo ku dhex mareysa xaafado ka tirsan degmada ...
Goodax oo eedeyn u jeediyay Madaxweynihii hore ee Soomaaliya Xasan Sheekh
- Mar 21, 2018
Xildhibaan C/llaahi Goodax Barre oo ka mid ah Xildhibaanada mooshinka ka keenay Guddoomiye Jawaari ...